Here is my current process for super tuning single cam bows. I have refined this process by tuning about 20 bows now with a wide range of arrows and broadheads. This is worth doing even if you plan to shoot mechanical heads as you will ensure you get optimal power to your arrow.
One of the major differences I have found is that cam lean must be correct to get bullet holes. And I do not adjust the rest side-to-side until I get the cam lean right for bullet holes through paper. Also, I will only shoot a bare shaft through paper. Fletching prevents getting a clear picture of how the arrow is flying.
If someone with experience with other cam set-ups, I'd like to hear how they differ. I'm not a Mathews fan boy, but I do own all Mathews bows which happen to be single cam bows. I have setup and tuned several Hoyt's that my friends own, but only did one twin-cam bow. Bowtech's are rare in southern California - I've only seen one.
Tools I use include bow press, bow vice, string level, arrow level, allen wrenches, paper tuning rack, and tape measure.
Super Tuning your Single-cam Bow
1. ensure arrows are stiff enough and straight, broadheads spin true, and fletching adds spin to the arrow
2. ensure string is in good shape
3. get bow into spec: ATA, cam timing, limb poundage, cam lean
4. set-up rest so that arrow is even with burger button, centered on string/cams (11/16" from riser to center of arrow on Mathews)
5. for single-cam bow, set-up nock point so nock is 1/8" to 3/16" high
6. shoot a bare shaft through paper until you get perfect bullet hole. Adjust cam lean until left/right tears are gone. For nock-left tear, add twists to right yolk. For nock-right tears, add twists to left yolk. Adjust rest up or down for nock-high or low tears. Principle is to move the arrow point to be in front of the arrow nock by adjusting the rest.
7. set top sight pin to top of sight guard. adjust sight gang so top pin is on at 20 yards with field points
8. On a windless day, broadhead tune at 20 yards, make micro adjustments to rest to move broadheads to field points, adjusting sight pin gang as necessary
9. broadhead tune from 30, 40, 50, 60, ... 100, set appropriate sight pin as necessary. I like Muzzy 3 blade for tuning because 1) they have practice blades that are easy to remove from target and 2) if they fly good, so do most other fixed heads.