people make too big of a deal of where the center of the bow is.
Set the arrow so it is close to the center of the hole. Adjust the rest from there. Ideally your knock level is slightly higher than the rest. This keeps the rear of the arrow from coming off the bow lower than the front causing all sorts of goofy problems. If you ever see Randy Ulmers pro tuning tips article, I strongly recommend reading it. He is arguably the greatest shooter ever and he really simplifies how to tune a bow. Also, your bow should be tuned so the knock point travel is level or travels slightly upward through the power stroke. This can be achieved through cam timing. This also keeps the rear of the arrow from spanking the rest on the way by. I wish I could still find the info and who did the testing, but someone used a shooting machine to test if the true center of the bow matters. If shooting away from the center changed timing etc. If tiller mattered. The big fat answer was no. The limbs, cams etc. will equalize no matter where the thing is drawn from. As archers we tend to be too anal about how everything is set up and tuned. We need to be more anal about our form than our tune and we would be better off.