Cam lean is unavoidable in cam systems that have control cables on only one side of the cam (99.99% of the bows on the market). These cam systems use a cable guard to allow fletching clearance. It is not the cable guard that causes cam lean though.
A shoot-through cam system such as the Martin Nitrous-X or Barnsdale Tri-star, has control cables on both sides of the cam.
This keeps the cam balanced when the cams letoff transfers the load from the string to the cables.
A split yoke control cable can be used to conceal cam lean, but it cannot eliminate it.
Cam lean can result in erratic arrow flight because of lateral change in nock travel. It is also one of the reasons that your sight pins are not aligned with the string and arrow after tuning is completed.
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