Need more info.
What type of rest are you using.
Have you checked for fletching clearance?
Have you checked for Idler or cam lean?
Has anyone checked to make sure you are not torquing the grip?
Is your bow in tune - Cam rotated properly, ATA and BH on spec?
What type of tuning method have you tried - Walk Back, Paper, etc?
Arrow spine is important, however, usually if arrow flight is very erratic, the first thing I look for is fletching contact. Once you have eliminated contact ENTIRELY, then you can start tuning. I don't even bother trying until I have checked for this. Good Luck!