I've found that with the wide axles, a single twist applies more torque to that side of the limb than the regular axles. It's a little harder to get both sides exactly even. Also, the cables take a more angled path across the draw stops.
That's why I liked the Doovawapi's. It let me actually put the cable spacers on backwards, which put the ends of the cables right next to the limbs, greatly reducing torque on the limbs, and allowing the cables to run right down the length of the draw stops, improving the wall a little. I could still fit 2613's with feathers, too.