Well I have some first hand experience on this subject. I have a RH HCA bow that I bought new in 94. Summer of 95 my right eye gets smacked by a tire tool. No more shooting RH for me. So, I let my father in law use the bow. Last winter I got the bow back from him (the string had been changed, but neither the sights nor rest were touched since I shot it last in 94. I shoot the bow as well if not better as I did RHed, and it hit to the same POI. FWIW, after about 500-600 shots the bow was out of tune badly. Also, wore the hush tubes on the rest pretty bad. Maybe shooting it LHed wore the tubes quicker, dont know. But, in any case it shoots the same RH or LH for me.